The factor V G1691A mutation is a risk for porencephaly: A case-control study
- 19 July 2004
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 56 (2) , 287-290
- https://doi.org/10.1002/ana.20184
Abstract
This study was initiated to investigate prothrombotic risk factors in children with porencephaly. 76 porencephalic and 76 healthy infants were investigated for factor V (FV) G1691A mutation, factor II G20210A variant, methylenetetrahydrofolate reductase (MTHFR) C677T genotype, lipoprotein (a), protein C, protein S, and antithrombin. Only the FV mutation (p = 0.005) and combinations of two or three different risk factors (p = 0.003) were significantly associated with porencephaly. These data give evidence that the FV G1691A mutation and a combination of prothromboic factors play a major role in the development of childhood porencephaly.Keywords
Funding Information
- Karl Bröcker foundation
- Foundation “Deutsche Schlaganfall-Hilfe.”
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