Core transcriptional regulatory circuitry in human hepatocytes
Open Access
- 1 January 2006
- journal article
- research article
- Published by Springer Nature in Molecular Systems Biology
- Vol. 2 (1) , 2006.0017
- https://doi.org/10.1038/msb4100059
Abstract
We mapped the transcriptional regulatory circuitry for six master regulators in human hepatocytes using chromatin immunoprecipitation and high‐resolution promoter microarrays. The results show that these regulators form a highly interconnected core circuitry, and reveal the local regulatory network motifs created by regulator–gene interactions. Autoregulation was a prominent theme among these regulators. We found that hepatocyte master regulators tend to bind promoter regions combinatorially and that the number of transcription factors bound to a promoter corresponds with observed gene expression. Our studies reveal portions of the core circuitry of human hepatocytes. Mol Syst Biol. 2: 2006.0017Keywords
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