Endotoxin administration decreases plasma insulin-like growth factor (IGF)-I and IGF-binding protein-2 in Angus × Hereford steers independent of changes in nutritional intake

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Abstract
Endotoxemia and sepsis cause severe shifts in metabolism towards catabolic events. The objective of the research was to determine whether endotoxin administration changes plasma concentrations of IGF-I and IGF-binding protein-2 (IGFBP-2) in Angus × Hereford steers. In Experiment 1, mean feed intake in endotoxin-treated steers (n=6) decreased 60% within the first 24 h after endotoxin and averaged, for the duration of the 96 h test period, an intake 35·5% lower than the mean ad libitum intake recorded prior to endotoxin. Plasma concentrations of IGF-I averaged 182 ng/ml in steers before endotoxin (E. coli, 055:B5, 0·2 μg/kg, i.v. bolus) and decreased an average of 24·2% at 24 to 96 h after endotoxin. In Experiment 2, a paired feeding strategy was used to determine whether the reduced feed intake was a significant factor in changing plasma concentrations of IGF-I and IGFBP-2 after endotoxin challenge. Steers were divided into endotoxin (0·2 μg/kg, i.v., n=6) or control (saline, n=6) n=3) treatments. Each of three endotoxin-treated steers was paired to a specific control. In this fashion, the adjusted feed intake of each endotoxin-treated steer was fed to it's paired control every 24 h through 96 h after endotoxin. After endotoxin, plasma concentrations of tumour necrosis factor-α (TNF) and cortisol peaked at one and three hours, respectively. TNF returned to baseline by 8 h while cortisol returned to baseline by 24 h. Feed intake declined 60% at 24 h in endotoxin-treated steers but returned to normal by 96 h. Plasma IGF-I remained more than 28% lower in endotoxin-treated steers than in control steers through 96 h (PPJournal of Endocrinology (1995) 144, 109–117

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