ENDOTOXEMIA AND ADRENAL HEMORRHAGE
Open Access
- 1 February 1965
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 121 (2) , 247-260
- https://doi.org/10.1084/jem.121.2.247
Abstract
Stimulation of the rabbit adrenal cortex by thorotrast, endotoxin or tropic hormone (ACTH) renders the adrenal cortex susceptible to the development of a hemorrhagic reaction during endotoxemia. The adrenal hemorrhage resembles that described in the Waterhouse-Fridericksen syndrome. Increased metabolic activity associated with the production of cortico-steroids seems to make the adrenal cortex susceptible to endotoxin. Adrenal hemorrhage observed during sepsis, as in the Waterhouse-Fridericksen syndrome may be attributable to endotoxemia occuring during or shortly after stimulation of the adrenal cortex by infection.Keywords
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