Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation
- 30 September 1986
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 64 (10) , 1324-1327
- https://doi.org/10.1139/y86-224
Abstract
Substance P (SP), injected intrathecally, produced a dose-related increase in responsiveness (hyperalgesia) in a pressure test for nociceptive thresholds. Pretreatment with two doses of SP produced complete desensitization to this response but did not alter base-line responsiveness. The hyperalgesic response to SP and the lack of change in base line following desensitization to SP suggest a modulator rather than a transmitter role for SP in the transmission of noxious mechanical stimulation.This publication has 3 references indexed in Scilit:
- Substance P: Evidence for spinal mediation of some behavioural effectsNeuropharmacology, 1981
- Depression and facilitation of synaptic responses in cat dorsal horn by substance P administered into substantia gelatinosaLife Sciences, 1980
- Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous systemNeuroscience, 1978