The resistance of Escherichia coli to oxytetracycline
- 1 September 1969
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Microbiology
- Vol. 15 (9) , 1077-1083
- https://doi.org/10.1139/m69-191
Abstract
The effects of oxytetracycline on sensitive and resistant strains of Escherichia coli were studied in relation to: (1) growth of bacteria in shaken cultures, (2) incorporation of amino acids into polypeptides by cell-free extracts, (3) binding of aminoacyl-tRNA to ribosomes. Our results support the hypothesis that resistance to the antibiotic is due to impermeability of bacteria to the drug.Evidence is also presented that there is no irreversible binding of oxytetracycline at ribosomal sites involved in protein synthesis.Keywords
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