Nitric Oxide and the Cardiovascular System
- 1 April 1994
- journal article
- review article
- Published by Hindawi Limited in Journal of Cardiac Surgery
- Vol. 9 (3) , 361-371
- https://doi.org/10.1111/j.1540-8191.1994.tb00857.x
Abstract
Nitric oxide is a simple diatomic molecule that functions as a cellular messenger in a number of organ systems, included among which is the cardiovascular system. Serving several physiologic roles in the cardiovascular system, nitric oxide is an important determinant of basal vascular tone, regulates myocardial contractility, and modulates platelet-vessel wall interactions. From the perspective of cardiovascular pathophysiology, nitric oxide has been implicated in the pathogenesis of essential hypertension, atherosclerosis, and the hypotension associated with shock states. This review will focus in detail on the chemistry, biology, and pathobiology of nitric oxide as it relates to cardiovascular function.Keywords
This publication has 73 references indexed in Scilit:
- Biochemistry of Nitric Oxide and Its Redox-Activated FormsScience, 1992
- Nitric oxide synthase is a cytochrome P-450 type hemoproteinBiochemistry, 1992
- Mammalian Nitric Oxide SynthasesPublished by Wiley ,1992
- Peroxynitrite oxidation of sulfhydryls.Journal of Biological Chemistry, 1991
- FAD and GSH participate in macrophage synthesis of nitric oxideBiochemical and Biophysical Research Communications, 1990
- Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.Proceedings of the National Academy of Sciences, 1990
- Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and NitrateJournal of Biological Chemistry, 1989
- Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediateBiochemistry, 1988
- Vascular endothelial cells synthesize nitric oxide from L-arginineNature, 1988
- Oxidation and reduction of hemoproteins by trioxodinitrate(II). The role of nitrosyl hydride and nitriteJournal of the American Chemical Society, 1988