Dopaminergic Modulation of Renin Release

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Abstract
The effect of metoclopramide, a procainamide derivative with dopamine antagonistic properties, and L-dopa on plasma renin activity (PRA) was studied in adult rats. Following an i.v. bolus of metoclopramide (200 .mu.g/kg) to the American Wistar rat there was a significant (P < 0.05) elevation in PRA at 10 min and a maximum response at 30 min. There was a significant depression (P < 0.05) in PRA at 15 through 40 min following an i.v. bolus of L-dopa (30 mg/kg). Pre-administration of L-dopa delayed and blunted the PRA response to metoclopramide. The PRA response to this dopamine antagonist was not altered by .beta. blockade with propranolol and .alpha. blockade with phentolamine. Metoclopramide administration resulted in considerably greater (P < 0.01) PRA responses in spontaneously hypertensive rats than in Wistar Kyoto (WKY) normotensive controls. L-dopa administration resulted in similar suppression of PRA in the 2 groups. There is evidently dopaminergic inhibitory control mechanism for renin secretion. Dopaminergic control of renin release appears to be altered in the spontaneously hypertensive rat.