Tamm-Horsfall Mucoproteins Promote Calcium Oxalate Crystal Formation in Urine: Quantitative Studies

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Abstract
The technique of rapid evaporation of whole [human] urine to standard osmolality was studied further and quantitative measurements made of the calcium oxalate crystals resulting, first by a microscope method and second by isotope method using 14C-oxalate. Ultrafiltration of urine prior to evaporation leads to a large reduction in calcium oxalate crystal fromation, and this is largely restored by addition of human urinary Tamm-Horsfall protein (uromucoid). Albumin does not have this effect.

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