Application of PNA and LNA oligomers to chemotherapy.

  • 1 April 2001
    • journal article
    • review article
    • Vol. 2  (4) , 558-61
Abstract
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.

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