The PKA‐CREB system encoded by the honeybee genome
Open Access
- 27 October 2006
- journal article
- Published by Wiley in Insect Molecular Biology
- Vol. 15 (5) , 551-561
- https://doi.org/10.1111/j.1365-2583.2006.00668.x
Abstract
The cAMP-dependent kinase (PKA) plays a crucial part in long-term memory formation in the honeybee (Apis mellifera). One of the putative substrates of the PKA activity is the cAMP response element binding protein (CREB), a transcription factor in the bZIP protein family. We searched the honeybee genome to characterize genes from the CREB/CREM and the PKA families. We identified two genes that encode regulatory subunits and three genes encode catalytic subunits of PKA. Eight genes code for bZIP proteins, but only one gene was found that encodes a member of the CREB/CREM family. The phylogenetic relationship of these genes was analysed with their Drosophila and human counterparts.Keywords
This publication has 55 references indexed in Scilit:
- Identification and characterization of novel PKA holoenzymes in human T lymphocytesThe FEBS Journal, 2005
- Synergistic activation of insect cAMP‐dependent protein kinase A (type II) by cyclicAMP and cyclicGMPFEBS Letters, 2004
- The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisationCellular Signalling, 2004
- Learning at Different Satiation Levels Reveals Parallel Functions for the cAMP–Protein Kinase A Cascade in Formation of Long-Term MemoryJournal of Neuroscience, 2004
- B-ZIP Proteins Encoded by the Drosophila Genome: Evaluation of Potential Dimerization PartnersGenome Research, 2002
- Nuclear post-transcriptional control of gene expressionJournal of Molecular Endocrinology, 2001
- Novel alternatively spliced mRNA (1c) of the protein kinase A RIα subunit is implicated in haploid germ cell specific expressionMolecular Reproduction and Development, 2001
- Two Novel Brain-specific Splice Variants of the Murine Cβ Gene of cAMP-dependent Protein KinasePublished by Elsevier ,1997
- FISH localization of the human Y-homolog of protein kinase PRKX (PRKY) to Yp11.2 and two pseudogenes to 15q26 and Xq12→q13Cytogenetic and Genome Research, 1997
- Isolation ofDrosophilaCREB-B: A Novel CRE-Binding ProteinDNA and Cell Biology, 1993