SYNTHESIS OF CARBOCYCLIC OROTIDINE ANALOGS AS POTENTIAL OROTIDINE DECARBOXYLASE INHIBITORS

31 December 2001

journal article
Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids

Vol. 20 (12) , 1915-1925
https://doi.org/10.1081/ncn-100108322

Abstract

An asymmetric synthesis of carbocyclic orotidine 15 and its monophosphate 16 were accomplished via the key intermediate cyclopentanone 4, which was prepared from D-gamma-ribonolactone in steps. None of synthesized the compounds inhibited orotidine 5'-monophosphate decarboxylase (EC 4.1.1.23) or orotate phosphoribosyltransferase (EC 2.4.2.10).

Keywords

ASYMMETRIC SYNTHESIS
CARBOCYCLIC OROTIDINE
SYNTHESIS OF CARBOCYCLIC
OROTIDINE ANALOGS
DECARBOXYLASE INHIBITORS
POTENTIAL OROTIDINE

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