Reactions of Functionalized 1,3-Dipoles

Abstract
A new synthetic approach to the formation of 5–5, 5–6, 5–5–5, and 6–5–6 fused heterocycles employing cycloadditions with functionalized dipoles is described and its scope and utility explored through representative examples. The regiochemistry and stereochemistry of the additions is established by specific deuterium labelling, n.m.r. spectroscopy, and by chemical means.

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