The role of placental gonadotrophins (PMSG and hCG) in pregnancy in the rat

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Abstract
Treatment of rats with anti-PMSG [pregnant mare''s serum gonadotropin] and anti-hCG [human chorionic gonadotropin] for 5 days from days 6, 11 or 16 of pregnancy caused variable necrosis of fetal tissue, the extent of which increased from the chorionic cells to the inner trophoblastic layers with the increase in dose from 4-10 mg anti-PMSG. At 10 mg/day, fetal death and resorption were invariable in early to mid-pregnancy, while in late pregnancy some litters were carried to term. The main histological change in the corpora lutea was hyperemia in the anti-PMSG-treated rats. Immunofluorescence studies with conjugates of anti-hCG and anti-PMSG showed sharp localization in the giant and chorionic cell layer at the feto-maternal junction. An hCG/PMSG-like substance is produced by rat chorionic cells that plays an immunosuppressive role during pregnancy.

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