Intact antibody response to pneumococcal capsular polysaccharides in uremia and diabetes

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Abstract
To test their immune responsiveness to pneumococcal (Streptococcus pneumoniae) polysaccharide antigens, 8 azotemic patients, 10 dialysis patients and 5 insulin-dependent diabetics were vaccinated with a 14-valent vaccine. When compared with nonazotemic, nondiabetic control subjects, diabetics and uremic patients responded with normal antibody titers to each antigen type. Immunization with commercially available vaccine in patients with diabetes, renal failure or both, although long-term efficacy has yet to be proved, is suggested.