The Discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists
- 20 December 2001
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 12 (4) , 611-614
- https://doi.org/10.1016/s0960-894x(01)00818-6
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- The discovery of small molecule carbamates as potent dual α4β1/α4β7 integrin antagonistsBioorganic & Medicinal Chemistry Letters, 2001
- The discovery of sulfonylated dipeptides as Potent VLA-4 antagonistsBioorganic & Medicinal Chemistry Letters, 2001
- Design and Synthesis of Potent and Selective Inhibitors of Integrin VLA-4Bioorganic & Medicinal Chemistry Letters, 2001
- Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway ResponsesJournal of Medicinal Chemistry, 1999
- Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and KetonesThe Journal of Organic Chemistry, 1999
- Improved Synthesis of Enantiopure Sulfinimines (Thiooxime S-Oxides) from p-Toluenesulfinamide and Aldehydes and KetonesThe Journal of Organic Chemistry, 1999
- The tert-Butanesulfinyl Group: An Ideal Chiral Directing Group and Boc-Surrogate for the Asymmetric Synthesis and Applications of β-Amino AcidsThe Journal of Organic Chemistry, 1998
- Asymmetric Synthesis of (R)-(+)-.beta.-Phenylalanine from (S)-(+)-Benzylidene-p-toluenesulfinamide. Regeneration of the Sulfinimine PrecursorThe Journal of Organic Chemistry, 1995
- Asymmetric synthesis of R-β-amino butanoic acid and S-β-tyrosine: Homochiral lithium amide equivalents for Michael additions to α,β-unsaturated esters.Tetrahedron: Asymmetry, 1991
- Structure of the Integrin VLA‐4 and its Cell‐Cell and Cell‐Matrix Adhesion FunctionsImmunological Reviews, 1990