p53: The Janus of autophagy?
- 1 June 2008
- journal article
- research article
- Published by Springer Nature in Nature Cell Biology
- Vol. 10 (6) , 637-639
- https://doi.org/10.1038/ncb0608-637
Abstract
The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.Keywords
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