WEGENERS GRANULOMATOSIS WITH SEVERE RENAL-FAILURE - CLINICAL COURSE AND RESULTS OF DIALYSIS AND TRANSPLANTATION

  • 1 January 1981
    • journal article
    • research article
    • Vol. 16  (4) , 172-180
Abstract
Nine patients with Wegener''s granulomatosis developed chronic renal failure and underwent chronic hemodialysis and transplantation. These patients are all young (< 43 yr); all except one are male. They present with acute renal failure that resolves with hemodialysis and immunosuppression, but then slowly develop chronic renal failure in spite of adequate immunosuppression. On chronic dialysis no manifestations of Wegener''s granulomatosis occur despite low or no immunosuppression in most of them. After transplantation the usual post-transplant immunosuppression regimen (azathioprine and prednisone) not only prevents rejection, but also controls the disease. In only one patient was it necessary to change from azathioprine to cyclophosphamide because of recurrence.

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