Serum Erythropoietin in Myelomatosis

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Abstract
Erythropoietin activity in serum was measured using 59Fe incorporation into erythrocytes in protein starved, hypoxic mice. The activity in serum from 20 patients with untreated myelomatosis was not significantly different from that in 31 saline controls. Only 3 patients had detectable erythropoietin levels in serum: 0.24 IU/ml, 0.27 IU/ml and 0.50 IU/ml (standard B), respectively. The venous hematocrit was correlated positively with the glomerular filtration rate as measured by 51Cr-EDTA clearance. No correlation could be established between venous hematocrit and serum albumin or serum transferrin. The results are in agreement with the assumption of defective erythropoietin activity due to renal failure in myelomatosis.

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