Are diet–prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men
Open Access
- 27 May 2003
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 88 (11) , 1682-1686
- https://doi.org/10.1038/sj.bjc.6600946
Abstract
We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet–cancer associations.Keywords
This publication has 30 references indexed in Scilit:
- Quality improvement report Improving design and conduct of randomised trials by embedding them in qualitative research: ProtecT (prostate testing for cancer and treatment) study Commentary: presenting unbiased information to patients can be difficultBMJ, 2002
- Are dietary influences on the risk of prostate cancer mediated through the insulin‐like growth factor system?BJU International, 2001
- Diet: Dairy Products, Calcium, and Vitamin D and Risk of Prostate CancerEpidemiologic Reviews, 2001
- Plasma Insulin-Like Growth Factor-I, Insulin-Like Growth Factor-Binding Proteins, and Prostate Cancer Risk: a Prospective StudyJNCI Journal of the National Cancer Institute, 2000
- Role of the Insulin-Like Growth Factor Family in Cancer Development and ProgressionJNCI Journal of the National Cancer Institute, 2000
- Invited Commentary: Tomatoes, Lycopene, and Prostate Cancer. How Strong Is the Evidence?American Journal of Epidemiology, 2000
- Dietary Changes Favorably Affect Bone Remodeling in Older AdultsJournal of the American Dietetic Association, 1999
- Breast-Feeding and Growth Factors in Preterm Newborn InfantsJournal of Pediatric Gastroenterology and Nutrition, 1997
- Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkersInternational Journal of Epidemiology, 1997
- Nutrition and prostate cancerCancer Causes & Control, 1996