Structural and evolutionary analysis of the two chimpanzee α-globin mRNAs
Open Access
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 11 (24) , 8915-8929
- https://doi.org/10.1093/nar/11.24.8915
Abstract
Two distinct α-globin mRNAs were detected in chimpanzee reticulocyte mRNA using a primer extension assay. DNA copies of these two mRNAs were cloned in the bacterial plasmid pBR322, and their sequence was determined. The two α-globin mRNAs have obvious structural homology to the two human α-globin mRNAs, α1 and α2. Comparison of the two chimpanzee α-globin mRNAs to each other and to their corresponding human counterparts revealed evidence of a recent gene conversion in the human α-globin complex and a marked heterogeneity in the rate of structural divergence within the α-globin gene.Keywords
This publication has 31 references indexed in Scilit:
- The untranslated regions of β-globin mRNA evolve at a functional rate in higher primatesCell, 1981
- The duplicated human α-globin genes: Their relative expression as measured by RNA analysisCell, 1981
- The adult β-globin genes of the “single” type mouse C57BLCell, 1981
- Evolution of the 87A and 87C heat-shock loci in DrosophilaNature, 1981
- Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype.Journal of Clinical Investigation, 1980
- The 3′ untranslated regions of the duplicated human α-globin genes are unexpectedly divergentCell, 1980
- A novel α-globin gene arrangement in manNature, 1980
- The complete sequence of a chromosomal mouse α-globin gene reveals elements conserved throughout vertebrate evolutionCell, 1979
- Deletion of α-globin genes in haemoglobin-H disease demonstrates multiple α-globin structural lociNature, 1975
- A complementation analysis of the restriction and modification of DNA in Escherichia coliJournal of Molecular Biology, 1969