Subacute encephalopathy after combination chemotherapy including moderate-dose methotrexate in a patient with gastric cancer
- 1 March 1999
- journal article
- case report
- Published by Wolters Kluwer Health in Anti-Cancer Drugs
- Vol. 10 (3) , 293-294
- https://doi.org/10.1097/00001813-199903000-00007
Abstract
An episode of subacute encephalopathy after the Infusion of a moderate dose of methotrexate (1500 mg/m2) (MTX) is reported in a young adult with metastastlc gastric cancer. Weakness of the right arm, focal seizures, lethargy and confusion appeared on day 10. High signal intensity in perlventricular white matter was observed on T2-welghted magnetic resonance Imaging. Symptoms resolved spontaneously and completely after 48 h. We believe that this represents an unusual case of moderate-dose MTX-lnduced neurotoxlcity In a patient with gastric cancer, which has not previously been reported.Keywords
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