Antimicrobial Peptides in Health and Disease
- 10 October 2002
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 347 (15) , 1199-1200
- https://doi.org/10.1056/nejme020106
Abstract
Microbes surround us. However, most of the time we are unaware of them. Our epithelial surfaces, which provide the physical barrier separating us from the environment, are usually free of signs of a battle taking place. Over the past several years, we have come to realize that the epithelium is capable of mounting its own battery of defensive chemicals, which are more extensive, more potent, and more exquisitely regulated than initially appreciated. I am referring not to the constituents of fluids, such as tears, saliva, and sweat, that are secreted onto the surface of epithelia, but to antimicrobial peptides, the . . .Keywords
This publication has 12 references indexed in Scilit:
- Endogenous Antimicrobial Peptides and Skin Infections in Atopic DermatitisNew England Journal of Medicine, 2002
- Toll-like Receptor 4 Polymorphisms and AtherogenesisNew England Journal of Medicine, 2002
- Discovery of five conserved β-defensin gene clusters using a computational search strategyProceedings of the National Academy of Sciences, 2002
- Antimicrobial peptides of multicellular organismsNature, 2002
- Toll-like receptors: critical proteins linking innate and acquired immunityNature Immunology, 2001
- Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T CellsThe Journal of Experimental Medicine, 2000
- Leukocyte granule proteins mobilize innate host defenses and adaptive immune responsesImmunological Reviews, 2000
- Structural features and biological activities of the cathelicidin-derived antimicrobial peptidesBiopolymers, 2000
- Antimicrobial Peptides as Mediators of Epithelial Host DefensePediatric Research, 1999
- A peptide antibiotic from human skinNature, 1997