Abstract
A 6 yr old girl suffering from chronic hemolytic anemia with crisis induced by drugs and infections was described. The disorder was diagnosed as an unstable-Hb hemolytic anemia. The heat stability test, simple and specific for unstable-Hb was mentioned and should be done in every child suffering from unexplained chronic hemolytic anemia. The Hb variant was also known in a patient in Brazil as Hb Niteroi.