Role of sperm-surface glycoproteins in gamete recognition in two mouse species

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Abstract
In-vitro fertilization and sperm binding to the zona pellucida within and between Mus musculus (laboratory mouse) and M. caroli (Asian wild field mouse) were examined. Maximum homologous sperm binding in M. musculus was 12.3 .+-. 0.3 spermatozoa bound per egg and in M. caroli, 9.2 .+-. 0.2. In heterologous crosses, sperm-zona binding was significantly reduced (M. musculus eggs with M. caroli spermatozoa, 1.9 .+-. 0.14; M. caroli eggs with M. musculus spermatozoa, 5.5 .+-. 0.2). Homologous sperm-zona interaction was inhibited by different sugars in the 2 mouse species (M. caroli by .alpha.-methyl mannose, M. musculus by sialic acid). Gamete recognition is highly species specific and hapten sugars play a significant role in sperm-zona binding.

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