In vitro uptake of IgA complexes by Kupffer cells

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Abstract
Cultured murine Kupffer cells were tested for their ability to bind TNP[trinitrophenyl]-sensitized erythrocytes coated with IgA myeloma proteins (MOPC 315 and 460) which have high affinity for TNP ligands and to ingest TNP-enzyme-IgA soluble immune complexes. In these experimental conditions, 6-18% of Kupffer cells expressed surface binding sites for IgA, a feature they share with lymphocytes and granulocytes. This functional property, also displayed by circulating monocytes, is thus maintained in liver-residing macrophages and may contribute to the regulation of immune response to gut-derived antigens.