Effect of Inhibition of Prostaglandin Synthesis on the Natriuresis Induced by Saline Infusion in Man

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Abstract
The effect of oral administration of an inhibitor of prostaglandin synthetase, indomethacin, on the natriuresis induced by the infusion of NaCl (saline) was studied in 11 healthy volunteers. The administration of indomethacin did not after Na excretion before saline infusion, but it resulted in a significant increase of the natriuresis after saline infusion. This increase was not accompanied by any change in post-infusion urine flow rate or free water reabsorption. Intrarenal prostaglandins might suppress the natriuretic effect of saline infusion, probably by increasing Na reabsorption in the distal nephron.