Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia
- 1 February 1980
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 137 (2) , 187-190
- https://doi.org/10.1176/ajp.137.2.187
Abstract
Serum neuroleptic levels were measured by radioreceptor assay in 30 schizophrenic patients receiving haloperidol, fluphenazine, chlorpromazine, molindone, thiothixene or trifluoperazine. Neuroleptic levels were significantly correlated with clinical state, monitored by an abbreviated version of the Present State Examination (the mini-PSE). Poor therapeutic responses were associated with serum levels under 50 ng/ml chlorpromazine equivalents. There was no correlation between neuroleptic dosage and mini-PSE score or between neuroleptic dose and serum neuroleptic levels.This publication has 1 reference indexed in Scilit:
- 3H-haloperidol binding to dopamine receptors in rat corpus striatum: Influence of chlorpromazine metabolites and derivativesEuropean Journal of Pharmacology, 1978