Thyroid Metabolism in Children and Adults Using Very Small (Nanocurie) Doses of Iodine125 and Iodine131

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Abstract
In addition to its medical importance, I131 is of interest because it is produced in large amounts in nuclear explosions and can deposit in the human thyroid via the food chain. Thyroid radio-iodine content is detectable by current human counting systems if over 50 pc. These facts, plus the need for uptake data on children, have prompted our investigation of a technique for measuring thyroid metabolism using doses of about 10 nc. An 8 × 4-in. NaI (Tl) spectrometer is used. Correction for thyroid depth in neck tissue is made using a mixture of 8-day I131 and 60-day I125; the ratio of the 27-keV X-radiation to the 364-keV γ-radiation detected by the crystal is a function of thyroid depth. Results on six normal adults show uptake at 7 days ranges from 15 to 29 per cent and on eight normal children from 9.5 to 27 per cent. Biological half times are similar (roughly 100 days) at this writing.

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