ANTIVIRAL ACTIVITY OF NORAKIN-R (TRIPERIDEN) AND RELATED ANTICHOLINERGIC ANTIPARKINSONISM DRUGS

  • 1 January 1984
    • journal article
    • research article
    • Vol. 28  (6) , 501-507
Abstract
In view of the coincidence of antiviral and antiparkinsonism activities of amantadine 4 antiparkinsonism drugs, Norakin (triperiden), Parkopan (trihexyphenidyl), Antiparkin (diethylbenzhydramine) and Akineton (biperiden) were tested for antiviral activity in various virus-cell systems. Norakin inhibited the replication of infleunza A viruses in chick embryo fibroblast, MDCK and Ehrlich ascites tumor cells. It also inhibited the replication of measles virus in Vero cells, 50% inhibitory concentrations being 2-6 .mu.g/ml. The drugs were also active against influenza B virus. Several representatives of other virus families, e.g., vaccinia, vesicular stomatitis, polio type 1 and herpes simplex type 1 viruses were insenstive to the compounds.

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