RADIOLABELED, NONSPECIFIC, POLYCLONAL HUMAN-IMMUNOGLOBULIN IN THE DETECTION OF FOCAL INFLAMMATION BY SCINTIGRAPHY - COMPARISON WITH GA-67-CITRATE AND TECHNETIUM-99M-LABELED ALBUMIN

  • 1 March 1989
    • journal article
    • research article
    • Vol. 30  (3) , 385-389
Abstract
The accumulation of nonspecific polyclonal human immunoglobulin (IgG) radiolabeled with 125I or 111In was compared to that of [67Ga]citrate and [99mTc]albumin in rats with deep thigh inflammation due to Escherichia coli infection. Serial scintigrams were acquired at 1, 3, 24, and in some cases, 48 hr after injection. As early as 3 hr postinjection, [111In]IgG showed greater accumulation at the lesion than [99mTc]HSA (p < 0.01). Both [125I]IgG and [111In]IgG showed greater accumulation than [67Ga]citrate (p < 0.01). At 24 hr, IgG image definition increased, while HSA image definition decreased, and the intensity of accumulation of both IgG preparations was greater than that of [67Ga]citrate or [99mTc]HSA (p < 0.01). At all imaging times, [67Ga]citrate accumulation was surprisingly low. In inflammtion produced by Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans, or turpentine, [111In]IgG accumulation was similar to the results obtained with E. coli. These studies suggest that focal sites of inflammation can be detected with radiolabeled nonspecific human polyclonal IgG.