GROWTH INHIBITION OF SARCOMA 180 BY HORMONE ANTISERA AND 5-FLUOROURACIL

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Abstract
Somatotrophic hormone antisera (STHAS) were prepared by the immunization of rabbits with purified bovine or human STH. The capacity of these antiserum preparations to inhibit the growth of experimental animal tumours was tested by giving daily injections to young Swiss mice bearing implants of Sarcoma 180. A significant inhibitory action of both bovine and human STHAS on the growth of Sarcoma 180 tumors was shown. This inhibitory effect was more marked in mice which had been inoculated at birth with the antiserum which was later injected during the period of tumour growth. The use of somatotrophic hormone antiserum treatment in combination with 5-fluorouracil proved to be somewhat more effective than the 5-FU alone. It was concluded that somatotrophic hormone antiserum offers promise as a tumour inhibitory agent and as adjuvant in carcino-therapy.