CHEMOTHERAPY OF PANCREATIC ADENOCARCINOMA - INITIAL REPORT ON 2 TRANSPLANTABLE MODELS IN THE SYRIAN-HAMSTER

  • 1 January 1982
    • journal article
    • research article
    • Vol. 42  (7) , 2666-2670
Abstract
Experimental evaluation of chemotherapy of pancreatic cancer has been limited by the lack of suitable animal models, which have only recently become available. This is the 1st report on the chemosensitivity of 2 transplantable animal models of pancreatic adenocarcinoma. The single-agent antitumor activity of 5-fluorouracil, cyclophosphamide, mitomycin C (MMC), methotrexate, actinomycin D, vincristine and 2 dose levels of Adriamycin (ADR) were tested against established palpable tumors of well-differentiated pancreatic ductal adenocarcinoma (WD PaCa), a solid tumor model of the Syrian hamster. None of the agents or dosages of ADR were effective against palpable WD PaCa tumors. ADR, MMC, streptozotocin and the combination of 5-fluorouracil, ADR and MMC were similarly ineffective when administered 1 wk after WD PaCa implantation, while tumors were still nonpalpable. The behavior of poorly differentiated pancreatic ductal adenocarcinoma (PD PaCa), an ascitic model of the Syrian hamster, was studied for comparison. In vivo, with survival as the end point, PD PaCa is markedly sensitive to ADR, perhaps weakly sensitive to MMC, and resistant to streptozotocin. In vitro clonogenic assays from cultured PD PaCa and WD PaCa confirmed the pattern of response seen in vivo. These recently developed pancreatic cancer models can be profitably used and compared, both in vivo and in vitro, as examples of relatively chemotherapy resistant (WD PaCa) and more sensitive (PD PaCa) tumor models.

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