Bromocriptine and domperidone in the treatment of Parkinson disease

Abstract
In a single-blind trial of therapy in 20 patients with idiopathic Parkinson disease, domperidone prevented nausea and vomiting induced by bromocriptine without diminishing beneficial central effects. Combination of the 2 drugs permitted rapid increase in bromocriptine dosage from 22.5 to 148 mg/day, with 71% mean clinical improvement over baseline score. Continuing efficacy of the regimen was evident for a mean follow-up of 2 mo.