Structure of the mouse glial fibrillary acidic protein gene: implications for the evolution of the intermediate filament multigene family
Open Access
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 13 (15) , 5527-5543
- https://doi.org/10.1093/nar/13.15.5527
Abstract
We report the complete sequence of the gene encoding mouse glial fibrillary acidic protein (GFAP), the intermediate filament (IF) protein specific to astrocytes. The 9.8 kb gene includes nine exons separated by introns ranging 1n size from 0.2 to 2.5 kb. A comparison of the organization of the GFAP gene with that of genes encoding other IF proteins reveals that the structure of IF genes Is highly conserved in spite of considerable divergence at the amino add level. Thus, most of the evolutionary events leading to the placement of introns 1n IF genes must have occurred prior to the duplication and subsequent divergence of IF genes from a presumptive common ancestral sequence. The conserved gene organization is unrelated to structural features of IFproteins.Keywords
This publication has 32 references indexed in Scilit:
- Complete sequence of a gene encoding a human type I keratin: sequences homologous to enhancer elements in the regulatory region of the gene.Proceedings of the National Academy of Sciences, 1985
- Genetics, evolution, and expression of the 68,000-mol-wt neurofilament protein: isolation of a cloned cDNA probe.The Journal of cell biology, 1985
- JC Virus Enhancer-Promoter Active in Human Brain CellsScience, 1984
- Remarkable conservation of structure among intermediate filament genesCell, 1984
- Sequence of a cDNA clone encoding mouse glial fibrillary acidic protein: structural conservation of intermediate filaments.Proceedings of the National Academy of Sciences, 1984
- Brain-specific genes have identifier sequences in their introns.Proceedings of the National Academy of Sciences, 1984
- A convenient and adaptable package of computer programs for DNA and protein sequence management, analysis and homology determinationNucleic Acids Research, 1984
- The structure of the vimentin geneCell, 1983
- Type I and type II keratins have evolved from lower eukaryotes to form the epidermal intermediate filaments in mammalian skin.Proceedings of the National Academy of Sciences, 1983
- Homology between theKpnI primate andBamHI (M1F-1) rodent families of long interspersed repeated sequencesNucleic Acids Research, 1983