Stereoselective acyclic synthesis via allylmetals: vicinal diols from γ-alkoxyallylaluminium compounds and aldehydes or ketones
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 15,p. 845-847
- https://doi.org/10.1039/c39820000845
Abstract
The reaction of in situ generated γ-alkoxyallylaluminium compounds with aldehydes or ketones at –78 °C leads to the highly diastereoselective formation of mono-protected vicinal diols; the precursor to exo-brevicomin was efficiently synthesised using this method.Keywords
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