IDENTIFICATION OF DENSE DEPOSIT DISEASE - REPORT FOR THE INTERNATIONAL STUDY OF KIDNEY-DISEASES IN CHILDREN

  • 1 January 1979
    • journal article
    • research article
    • Vol. 103  (2) , 67-72
Abstract
The fluorescent dye thioflavine T intensely stains the deposits in dense deposit disease and can be used for identification purposes. Comparison of thioflavine T staining with EM was carried out in 25 patients and showed excellent congruity. Thioflavine T is much easier to use, but is less specific than EM. Cases of light chain disease and of some gammopathies can be a source of confusion. In nearly all other instances, the pattern of staining helps to differentiate dense deposits from other types of deposits and from amyloid.