IMMUNOHISTOCHEMICAL STUDIES OF ULCERATIVE COLITIS With Special Reference to Localization of Immunoglobulins, Secretory Component, and Lysozyme in View of Suffering Periods

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Abstract
Surgically resected large bowels with ulcerative colitis (UC) and biopsied specimens from UC patients were studied immunohistochemically in terms of localization of immunoglobulins, secretory component (SC), complement C3 and lysozyme in relation to the suffering periods. In the longstanding group (suffering periods > 9 mo.) of UC, a marked decrease or absence of IgA, as well as IgM, was frequently observed in the columnar epithelial cells despite residue of SC positivity. However, in the shortstanding group (suffering periods from 1-4 mo.) both SC and IgA were well preserved in the apical portion of the epithelial cells in a similar manner as observed in the control group. There was moderate to marked increase of IgM-producing cells in the majority of the UC cases regardless of suffering periods. Lysozyme was not demonstrable in the normal epithelial cells of the large intestine but occasionally observed in those of UC cases.