A STUDY OF THE INTRAGASTRIC FACTORS IN THE REGULATION OF GASTRIC ACIDITY

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Abstract
The whole stomach possesses very little ability to lower the acidity of acid solutions introduced into it. The secretion of the whole stomach is composed of 2 fractions: (a) acid, with a chloride conc. of 578-604 mgm.%, and (b) non-acid, with a chloride conc, of ca. 335 mgm.%. The amt. of the non-acid secretion is rather limited (2-14 cc. for 1/2 hr. periods), and is apparently independent of the amt. of acid secretion. The av. alkalinity of the non-acid secretion was 0.04 [image]. The total amt. of neutral chloride in the isolated stomach is rather small and does not rise as the acid secretion falls. These studies indicate that the most important intragastric factor in the regula tion of gastric acidity is the intensity of the stimulus for acid secretion.

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