The Doppler‐Derived Myocardial Performance Index Is Determined by Both Left Ventricular Systolic and Diastolic Function as Well as by Afterload and Left Ventricular Mass

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Abstract
Objectives: To investigate if the newly developed Doppler-derived myocardial performance index (MPI, also denoted TEI-index) is associated with variables reflecting both left ventricular (LV) systolic and diastolic function, as well as variables reflecting preload, afterload, and LV geometry. Material: An echocardiographic examination including Doppler was carried out in 446 men aged 70 in a population-based survey (the ULSAM-study, Uppsala Longitudinal Study of Adult Men). Results: In multiple regression analysis, MPI was independently associated with ejection fraction (P < 0.001), E/A ratio (P < 0.001), total peripheral resistance index (P < 0.001), stroke volume to pulse pressure ratio (P < 0.02), stroke index (P < 0.01), and LV mass (P < 0.04), but not with heart rate or blood pressure. Conclusion: The echocardiographically determined myocardial performance index is determined by both LV systolic and diastolic function as well as by afterload and left ventricular mass.

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