ANORGASMIA ASSOCIATED WITH IMIPRAMINE BUT NOT DESIPRAMINE - CASE-REPORT

  • 1 January 1983
    • journal article
    • research article
    • Vol. 44  (9) , 345-346
Abstract
A case of imipramine-induced orgasmic inhibition in a woman [with depression] is reported. Desipramine, the metabolite of imipramine, did not produce this reaction. The ability of imipramine to block the CNS neuronal reuptake of serotonin (a property not shared by desipramine) is considered the probable pathophysiologic mechanism in the failure to achieve orgasm.