Metabolic database systems for the analysis of genome‐wide function
- 30 December 2003
- journal article
- review article
- Published by Wiley in Biotechnology & Bioengineering
- Vol. 84 (7) , 750-755
- https://doi.org/10.1002/bit.10881
Abstract
Genome sequencing projects provide an inventory of molecular components for a wide variety of organisms. Metabolic databases integrate these functional descriptions of individual modules into a higher‐level characterization of cellular metabolism. This article reviews efforts related to the development of metabolic databases and discusses how such systems have aided the delineation of genome properties. We illustrate the design features of metabolic databases and discuss the challenges facing metabolic as well as databases of other functional type. © 2003; Wiley Periodicals, Inc.Keywords
This publication has 58 references indexed in Scilit:
- Comprehensive Analysis of the Mouse Metabolome Based on the TranscriptomeGenome Research, 2003
- The Phylogenetic Extent of Metabolic Enzymes and PathwaysGenome Research, 2003
- Combined transcriptome and proteome analysis of Escherichia coli during high cell density cultureBiotechnology & Bioengineering, 2003
- Determination of Redundancy and Systems Properties of the Metabolic Network of Helicobacter pylori Using Genome-Scale Extreme Pathway AnalysisGenome Research, 2002
- A structural census of metabolic networks for E. coliJournal of Molecular Biology, 2001
- The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coliJournal of Molecular Biology, 2001
- Prediction of protein interactions: metabolic enzymes are frequently involved in gene fusionNature Genetics, 2000
- Integrated pathway–genome databases and their role in drug discoveryTrends in Biotechnology, 1999
- A Database for Cell Signaling NetworksJournal of Computational Biology, 1998
- Metabolism and evolution of Haemophilus influenzae deduced from a whole-genome comparison with Escherichia coliCurrent Biology, 1996