Multitasking of Ig-α and Ig-β to Regulate B Cell Antigen Receptor Function
- 1 January 2001
- journal article
- review article
- Published by Taylor & Francis in International Reviews of Immunology
- Vol. 20 (6) , 679-696
- https://doi.org/10.3109/08830180109045585
Abstract
Since their discovery as signaling subunits of the B cell antigen receptor (BCR), Ig-α and Ig-β are discussed to serve either a redundant or distinct function for B cell development, maintenance, and activation. Dependent upon the experimental system that has been used to address this issue, evidence could be provided to support both possibilities. Only recently has it become clear that Ig-α and Ig-β possess a unique signaling identity but that both together are required to orchestrate proper B cell function in vivo. Here we discuss some of the underlying mechanisms that may involve direct coupling to discrete subsets of BCR effector proteins, such as protein tyrosine kinases or the intracellular adaptor SLP-65/BLNK.Keywords
This publication has 104 references indexed in Scilit:
- Hematopoietic cell‐specific adapter proteins, SLP‐76 and BLNK, effectively activate NF‐AT as well as NF‐κB by Syk and Tec PTKs in non‐lymphoid cell linesFEBS Letters, 2001
- Ig-α Cytoplasmic Truncation Renders Immature B Cells More Sensitive to Antigen ContactImmunity, 1999
- A Negative Regulatory Role for Ig-α during B Cell DevelopmentImmunity, 1999
- Structural basis for syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptideJournal of Molecular Biology, 1998
- Mutations in the Human λ5/14.1 Gene Result in B Cell Deficiency and AgammaglobulinemiaThe Journal of Experimental Medicine, 1998
- The Immunoglobulin (Ig)α and Igβ Cytoplasmic Domains Are Independently Sufficient to Signal B Cell Maturation and Activation in Transgenic MiceThe Journal of Experimental Medicine, 1997
- The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.The Journal of Experimental Medicine, 1995
- Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease proteinCurrent Biology, 1995
- B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and FynCurrent Biology, 1993
- Characterization of molecular components associated with surface immunoglobulin M in human B lymphocytes: Presence of tyrosine and serine/threonine protein kinasesEuropean Journal of Immunology, 1992