Unique quadruplex structures of d(GGA)4 (12-mer) and d(GGA)8 (24-mer)--Direct evidence of the formation of non-canonical base pairs and structural comparison--
Open Access
- 1 November 2002
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Symposium Series
- Vol. 2 (1) , 49-50
- https://doi.org/10.1093/nass/2.1.49
Abstract
Genetic predisposition has been implicated in the pathogenesis of mental disorders including schizophrenia. Mitochondrial dysfunction has been shown to be associated with mitochondrial myopathies, type 2 diabetes. We encountered with a diabetic woman who was associated with mitochondrail myopathy and schizophrenia. To know an involvement of mitochondrial DNA abnormalities in the pathogenesis of psychiatric diseases, we screened patients with schizophrenia for mitochondrial DNA abnormalities. By screening for an A3243G mutation of the tRNA(LEU) of the mitochondrial DNA, no one carried this mutation. Other mutations were also analysed. Although some mitochondrial DNA abnormalities may be associated with schizophrenia, the A3 2 43 G mutation is unlikely to play a major role in the pathogenesis of schizophrenia in Japanese.Keywords
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