Association between a Defective CCR-5 Gene and Progression to Disease in HIV Infection
- 20 September 1998
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 14 (14) , 1229-1234
- https://doi.org/10.1089/aid.1998.14.1229
Abstract
We measured the effect(s) of CCR-5 genotype on disease progression by studying the frequency of a defective CCR-S Δ32 allele within a cohort of long-term infected individuals. An elevated frequency of CCR-5 Δ32 heterozygotes within the cohort compared with a control population of blood donors was observed. An association between progression rate and CCR-5 Δ32 heterozygosity was observed. Furthermore, analysis of proviral DNA V3 sequences from a subset of the cohort predicted that the majority of individuals (39 of 44) were infected with viruses predicted to utilize the β-chemokine receptor CCR-5. The marked association between CCR-5 genotype and disease progression observed in this study may be a consequence of the predicted low frequency of CXCR-4-utilizing viruses present within the selected cohort.Keywords
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