Gas-liquid chromatographic estimation in blood of ICI 58 834
- 1 October 1973
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 25 (10) , 800-802
- https://doi.org/10.1111/j.2042-7158.1973.tb09944.x
Abstract
The blood levels attained at therapeutic oral doses of ICI 58 834 hydrochloride, a novel psychotropic agent, are adequately assayed by gas-liquid chromatography. The free base is extracted into benzene and converted to its heptafluorobutyrate derivative. The derivative is chromatographed on a column of 1% XE60 on Gas-Chrom Q and detected by electron capture. Recovery from blood is 80–90% and the minimum detectable level is about 20 ng compound ml−1 whole blood.Keywords
This publication has 1 reference indexed in Scilit: