A rapid quantitative method for the preparation of 123I-iodo-hippuric acid
- 1 February 1982
- journal article
- research article
- Published by Springer Nature in European Journal of Nuclear Medicine and Molecular Imaging
- Vol. 7 (2) , 58-61
- https://doi.org/10.1007/bf00251643
Abstract
The labelling of o-iodo-hippuric acid (hippuran) with 123I by several methods was investigated with a view to producing a simple one-step kit preparation. The requirements for the final product are high labelling efficiency and high radiochemical purity. A method which incorporates CuSO4·5H2O as a catalyst was found which gave promising preliminary results. Such variables as pH, mass of CuSO4·5H2O, volume of 0.02 N NaOH containing the 123I, reaction temperature and time were investigated in detail and optimum values obtained. The results have led to the production of a kit which can be stored for up to 3 months in liquid form and up to 9 months if freeze-dried. The kit has been used in several thousand patients and has yielded consistently good clinical results.Keywords
This publication has 4 references indexed in Scilit:
- A review of the physiological parameters in the dosimetry of 123I and 131I-labelled HippuranThe International Journal of Applied Radiation and Isotopes, 1978
- The preparation of 123I labelled sodium-ortho-iodo hippurate for medical researchThe International Journal of Applied Radiation and Isotopes, 1976
- The preparation of iodine-123 labelled sodium ortho-iodo hippurate and its clearance by the rat kidneysThe International Journal of Applied Radiation and Isotopes, 1975
- Preparation of 131I-labelled m-iodohippuric acid and its behaviour in kidney function studies compared to o-iodohippuric acidThe International Journal of Applied Radiation and Isotopes, 1973