Inositol-1-Phosphatase in the Lens

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Abstract
The ocular lens has high concentrations of free myoinositol. The ability of the lens to actively concentrate inositol may explain the high levels of the cyclic polyol. However, no detectable amounts of inositol are present in the aqueous humor. The biosynthesis of inositol may contribute to the inositol stores in the lens. This paper describes a study on the various factors involved in explaining the presence of inositol in the lens. During the course of this study an active phosphatase of inositol-1-phosphate was uncovered. Consequently, this paper deals primarily with the phosphatase and also gives some features of the biosynthesis of inositol from glucose-6-phosphate in the lens.

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