GENUINE GIANT-CELL TUMOR OF BONE - COMBINED CYTOLOGICAL, HISTOPATHOLOGICAL AND ULTRASTRUCTURAL-STUDY

  • 1 January 1976
    • journal article
    • research article
    • Vol. 11  (2) , 117-127
Abstract
Three patients with a giant cell tumor of bone were studied clinically, roentgenologically and morphologically, using cytological, histopathological and EM methods. The tumors were composed of giant cells possessing a great number of mitochondria, and stromal cells exhibiting prominent endoplasmic reticulum and Golgi complex. Mitotic activity was only found among the stromal cells. Autophagic vacuoles, lysosomal bodies and degenerative changes of varying severity were found mainly or exclusively among the giant cells, which may indicate that these cells represent an involutionary form of tumor cell. The giant cell tumors of bone are believed to arise from undifferentiated cells of the bone marrow. Fine needle aspiration biopsy represents a valuable complement to histopathological examination in the identification of giant cell lesions and diagnosis of genuine giant cell tumors of bone.

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