A DIFFUSIBLE LYMPHOKINE PRODUCED BY CD8+ LYMPHOCYTES-T SUPPRESSES HIV REPLICATION

  • 1 April 1989
    • journal article
    • research article
    • Vol. 66  (4) , 628-630
Abstract
Peripheral blood CD8+ T lymphocytes from human immunodeficiency virus (HIV)-infected individuals suppress replication of HIV in peripheral blood mononuclear cells (PBMC). This anti-viral activity appears to be mediated in part by a diffusible factor. Production of this lymphokine varies among infected individuals and may reflect the intrinsic ability of an individual''s CD8+ cells to control HIV infection. In some cases in which factor activity is not apparent, contact of the CD8+ cells with infected CD4+ cells can produce for suppression of virus replication. These observations could lead to approaches for enhancing anti-viral responses in HIV-infected individuals.

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